Short term low-calorie diet improves insulin sensitivity and metabolic parameters in obese women

Nutrición Hospitalaria

Glorimar Rosa¹  Sofia Kimi Uehara¹  Grazielle Vilas Bôas Huguenin²  Egberto Gaspar de Moura²  José Firmino Nogueira Netto²  Magna Cottini da Fonseca Passos² 

[1] Federal University of Rio de Janeiro;State University of Rio de Janeiro;

关键词: Obesidad;    Dieta hipocalórica;    Insulina;    Adiponectina;    Peso corporal;   

DOI  :  10.3305/nh.2014.30.1.7464

来源: DOAJ

【 摘 要 】

Obesity and insulin resistance are associated with an increase of cardiovascular risk factors, including adipocytokines. The aim of this study was to investigate the effect of low-calorie diet on serum lipids, adipokines, insulin resistance and body composition in obese women. It was a clinical trial with class I obese women aged 30-45 years submitted to hypocaloric diet for 90 days. Dietary intake, anthropometric parameters, body composition, serum lipids, glucose, insulin, leptin, adiponectin, HOMA-IR and QUICKI indexes were evaluated at the baseline, 30, 60 and 90 days. There was 30% significant decrease in energy intake, and also decrease in body weight, body mass index and waist circumference (p < 0.01) throughout the treatment period. Despite the amount of lean body mass (kg) reduced in average, it was observed that lean body mass (%) had increased (p < 0.01) and that the amount of fat body mass (kg) had decreased significantly in the third month (p < 0.05). Systolic blood pressure reduced up to -5mmHg (p < 0.05) after 90 days. Was observed a decrease (p < 0.05) on serum insulin and HOMA-IR until the 60th day, while the serum adiponectin increased (p < 0.01) during treatment. Corroborating with the reduction of fat body mass and weight, serum leptin also reduced (p < 0.01). These results suggest that the short-term low-calorie diet reduces total body fat, mainly found in the abdominal region, and efficiently improve insulin sensitivity decreasing cardiovascular risk in obese women.

【 授权许可】

Unknown