Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies

International Journal of Molecular Sciences

KonduruS. Sastry¹  AouatefI. Chouchane¹  Meenakshi Umar¹ 

[1] Division of Translational Medicine, Research Department, Sidra Medicine, P.O. Box 26999 Doha, Qatar;

关键词: vitamin D;    non-phosphocalcic action;    cellular functions;    immune regulation;    clinical effect;   

DOI  :  10.3390/ijms19061618

来源: DOAJ

【 摘 要 】

The classical function of Vitamin D, which involves mineral balance and skeletal maintenance, has been known for many years. With the discovery of vitamin D receptors in various tissues, several other biological functions of vitamin D are increasingly recognized and its role in many human diseases like cancer, diabetes, hypertension, cardiovascular, and autoimmune and dermatological diseases is being extensively explored. The non-classical function of vitamin D involves regulation of cellular proliferation, differentiation, apoptosis, and innate and adaptive immunity. In this review, we discuss and summarize the latest findings on the non-classical functions of vitamin D at the cellular/molecular level and its role in complex human diseases.

【 授权许可】

Unknown