A review of the immunomodulatory activities of polysaccharides isolated from Panax species

Journal of Ginseng Research

Yang He¹  Ting Shen¹  Jae Youl Cho¹  Xinfeng Wang¹  Zhiqiang Niu²  Weicheng Hu²  Yeye Hu²  Ji Zhang² 

[1] Environmental protection/Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, Huaiyin Normal University, Huaian, China;;Jiangsu Collaborative Innovation Center of Regional Modern Agriculture &

关键词: Panax polysaccharide;    Composition;    Immunomodulatory;    Membrane receptor;    Signalling pathway;   

DOI  :  

来源: DOAJ

【 摘 要 】

Panax polysaccharides are biopolymers that are isolated and purified from the roots, stems, leaves, flowers, and fruits of Panax L. plants, which have attracted considerable attention because of their immunomodulatory activities. In this paper, the composition and structural characteristics of purified polysaccharides are reviewed. Moreover, the immunomodulatory activities of polysaccharides are described both in vivo and in vitro. In vitro, Panax polysaccharides exert immunomodulatory functions mainly by activating macrophages, dendritic cells, and the complement system. In vivo, Panax polysaccharides can increase the immune organ indices and stimulate lymphocytes. In addition, this paper also discusses the membrane receptors and various signalling pathways of immune cells. Panax polysaccharides have many beneficial therapeutic effects, including enhancing or activating the immune response, and may be helpful in treating cancer, sepsis, osteoporosis, and other conditions. Panax polysaccharides have the potential for use in the development of novel therapeutic agents or adjuvants with beneficial immunomodulatory properties.

【 授权许可】

Unknown