SARS-CoV-2 mutations acquired in mink reduce antibody-mediated neutralization

Cell Reports

Nadine Krüger¹  Hans-Martin Jäck²  Lu Zhang²  Hannah Kleine-Weber²  Joachim Riggert²  Heike Hofmann-Winkler³  Martin Sebastian Winkler³  Amy Kempf³  Sebastian Schulz³  Markus Hoffmann³  Stefan Nessler³  Luise Graichen³  Stefan Pöhlmann⁴ 

[1] Corresponding author;Faculty of Biology and Psychology, University Göttingen, Wilhelmsplatz 1, 37073 Göttingen, Germany;Infection Biology Unit, German Primate Center – Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, Germany;Institute of Neuropathology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany;

关键词: SARS-CoV-2;    spike protein;    mink;    mutation;    variant;    Y453F;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from humans to farmed mink has been observed in Europe and the US. In the infected animals, viral variants arose that harbored mutations in the spike (S) protein, the target of neutralizing antibodies, and these variants were transmitted back to humans. This raised concerns that mink might become a constant source of human infection with SARS-CoV-2 variants associated with an increased threat to human health and resulted in mass culling of mink. Here, we report that mutations frequently found in the S proteins of SARS-CoV-2 from mink are mostly compatible with efficient entry into human cells and its inhibition by soluble angiotensin-converting enzyme 2 (ACE2). In contrast, mutation Y453F reduces neutralization by an antibody with emergency use authorization for coronavirus disease 2019 (COVID-19) therapy and sera/plasma from COVID-19 patients. These results suggest that antibody responses induced upon infection or certain antibodies used for treatment might offer insufficient protection against SARS-CoV-2 variants from mink.

【 授权许可】

Unknown