ST2 levels increased and were associated with changes in left ventricular systolic function during a three-year follow-up after adjuvant radiotherapy for breast cancer

Breast

Suvi Tuohinen¹  Vesa Virtanen²  Tanja Skyttä³  Eeva Moilanen⁴  Tiina Luukkaala⁵  Hanna Aula⁶  Mari Hämäläinen⁷  Pekka Raatikainen⁸  Pirkko-Liisa Kellokumpu-Lehtinen⁹ 

[1] Corresponding author. Department of Oncology, Tampere University Hospital, P.O. Box 2000, 33521, Tampere, Finland.;Department of Cardiology, Heart and Lung Center, Helsinki University Hospital, PO Box 340, 00029, HUS, Finland;Department of Oncology, Tampere University Hospital, PO Box 2000, 33521, Tampere, Finland;Health Sciences, Faculty of Social Sciences, Tampere University, 33014, Tampere University, Finland;Department of Oncology, Tampere University Hospital, PO Box 2000, 33521, Tampere, Finland;Faculty of Medicine and Health Technology, Tampere University, 33014, Tampere University, Finland;Heart Hospital, Tampere University Hospital, PO Box 2000, 33521, Tampere, Finland;Research, Innovation and Development Center, Tampere University Hospital, PO Box 2000, 33521, Tampere, Finland;The Immunopharmacology Research Group, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 33014, Tampere University, Finland;

关键词: ST2;    Cardiotoxicity;    Breast cancer;    Radiotherapy;    Echocardiography;    Left ventricular systolic function;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objectives: To search for biomarkers of RT-induced cardiotoxicity, we studied the behavior of ST2 during RT and three years after RT, and the associations with echocardiographic changes. Materials and methods: We measured soluble ST2 (ng/ml) in serum samples from 63 patients receiving RT for early breast cancer. Sampling and echocardiography were performed at baseline, after RT and at the three-year follow-up. Patients were grouped by >15% (group 1) and ≤15% (group 2) relative worsening in global longitudinal strain (GLS). Results: ST2 levels tended to increase during RT, from a median (interquartile range; IQR) of 17.9 (12.4–22.4) at baseline to 18.2 (14.1–23.5) after RT (p = 0.075). By the three-year follow up, ST2 levels increased to 18.7 (15.8–24.2), p = 0.018. The increase in ST2 level was associated with worsening cardiac systolic function at three-year follow-up, GLS (rho = 0.272, p = 0.034) and left ventricular ejection fraction (LVEF) (rho = ─0.343, p = 0.006). Group 1 (n = 14) had a significant increase in ST2 levels from 17.8 (12.3–22.5) at baseline to 18.4 (15.6–22.6) after RT, p = 0.035 and to 19.9 (16.0–25.1) three years after RT, p = 0.005. ST2 levels were stable in group 2 (n = 47): 17.8 (12.3–22.0) at baseline, 17.7 (12.6–23.5) after RT and 18.0 (15.5–22.4) at three years. Conclusion: ST2 may be useful for determining which patients are at risk for long-term cardiovascular toxicity following adjuvant breast cancer RT, but prospective clinical studies are needed to confirm this hypothesis.

【 授权许可】

Unknown