Comparison of antinociceptive effect of the antiepileptic drug gabapentin to that of various dosage combinations of gabapentin with lamotrigine and topiramate in mice and rats

Journal of Neurosciences in Rural Practice

BP Das¹  GP Rauniar¹  Keshab Raj Paudel²  SK Bhattacharya³ 

[1] Departments of Pharmacology, B. P. Koirala Institute of Health Sciences, Dharan, Nepal,;Departments of Pharmacology, Kathmandu Medical College and Teaching Hospital, Kathmandu,;Departments of Pharmacology, University College of Medical Sciences, New Delhi, India;

关键词: analgesia;    formalin assay;    gabapentin;    lamotrigine;    mechanical hyperalgesia;    radiant heat;    topiramate;    thermal nociception;   

DOI  :  10.4103/0976-3147.83577

来源: DOAJ

【 摘 要 】

Introduction: Newer anticonvulsants have a neuromodulatory effect on pain perception mechanisms in a hyperexcitable and damaged nervous system. Aim: This study was designed to study the analgesic effects of gabapentin alone and in combination with lamotrigine and topiramate in experimental pain models. Materials and Methods: Adult albino mice (n = 490) weighing 20–30 g and rats (n = 130) weighing 100–200 g were injected intraperitoneally with gabapentin, lamotrigine, and topiramate alone and in different dose combinations. The hot-plate method, tail-flick method, capsaicin-induced mechanical hyperalgesia, and formalin assay were used to assess the antinociceptive effects. Results: Of the three antiepileptic drugs, when given separately, gabapentin was more efficacious than either topiramate or lamotrigine in all the pain models. Combination of 25 mg/kg gabapentin with 25 mg/kg topiramate was more efficacious (P <.05) than 50 mg/kg gabapentin alone in the capsaicin-induced mechanical hyperalgesia test. Similarly, 50 mg/kg gabapentin with 50 mg/kg topiramate or 5 mg/kg lamotrigine was more efficacious (P <.05) than 50 or 100 mg/kg gabapentin alone in late-phase formalin-induced behaviors. Conclusions: Combination of gabapentin with either lamotrigine or topiramate produced better results than gabapentin alone in capsaicin-induced mechanical hyperalgesia test and in late-phase formalin-induced behaviors.

【 授权许可】

Unknown