Journal of Neurosciences in Rural Practice | |
Comparison of antinociceptive effect of the antiepileptic drug gabapentin to that of various dosage combinations of gabapentin with lamotrigine and topiramate in mice and rats | |
BP Das1  GP Rauniar1  Keshab Raj Paudel2  SK Bhattacharya3  | |
[1] Departments of Pharmacology, B. P. Koirala Institute of Health Sciences, Dharan, Nepal,;Departments of Pharmacology, Kathmandu Medical College and Teaching Hospital, Kathmandu,;Departments of Pharmacology, University College of Medical Sciences, New Delhi, India; | |
关键词: analgesia; formalin assay; gabapentin; lamotrigine; mechanical hyperalgesia; radiant heat; topiramate; thermal nociception; | |
DOI : 10.4103/0976-3147.83577 | |
来源: DOAJ |
【 摘 要 】
Introduction: Newer anticonvulsants have a neuromodulatory effect on pain perception mechanisms in a hyperexcitable and damaged nervous system. Aim: This study was designed to study the analgesic effects of gabapentin alone and in combination with lamotrigine and topiramate in experimental pain models. Materials and Methods: Adult albino mice (n = 490) weighing 20–30 g and rats (n = 130) weighing 100–200 g were injected intraperitoneally with gabapentin, lamotrigine, and topiramate alone and in different dose combinations. The hot-plate method, tail-flick method, capsaicin-induced mechanical hyperalgesia, and formalin assay were used to assess the antinociceptive effects. Results: Of the three antiepileptic drugs, when given separately, gabapentin was more efficacious than either topiramate or lamotrigine in all the pain models. Combination of 25 mg/kg gabapentin with 25 mg/kg topiramate was more efficacious (P <.05) than 50 mg/kg gabapentin alone in the capsaicin-induced mechanical hyperalgesia test. Similarly, 50 mg/kg gabapentin with 50 mg/kg topiramate or 5 mg/kg lamotrigine was more efficacious (P <.05) than 50 or 100 mg/kg gabapentin alone in late-phase formalin-induced behaviors. Conclusions: Combination of gabapentin with either lamotrigine or topiramate produced better results than gabapentin alone in capsaicin-induced mechanical hyperalgesia test and in late-phase formalin-induced behaviors.
【 授权许可】
Unknown