Research progress of the engagement of inorganic nanomaterials in cancer immunotherapy

Drug Delivery

Xinghui Liu¹  Tingwei Peng²  Tianzhao Xu³ 

[1] Department of Clinical Laboratory, Gongli Hospital, School of Medicine, Shanghai University, Shanghai, China;Postgraduate Training Base in Shanghai Gongli Hospital, Ningxia Medical University, Pudong New Area, China;Shanghai Qiansu Biological Technology Co., Ltd, Pudong New Area, China;

关键词: Inorganic nanomaterials;    tumor immunity;    cancer vaccine;    tumor microenvironment;    chemoimmunotherapy;   

DOI  :  10.1080/10717544.2022.2086940

来源: DOAJ

【 摘 要 】

Cancer has attracted widespread attention from scientists for its high morbidity and mortality, posing great threats to people’s health. Cancer immunotherapy with high specificity, low toxicity as well as triggering systemic anti-tumor response has gradually become common in clinical cancer treatment. However, due to the insufficient immunogenicity of tumor antigens peptides, weak ability to precisely target tumor sites, and the formation of tumor immunosuppressive microenvironment, the efficacy of immunotherapy is often limited. In recent years, the emergence of inorganic nanomaterials makes it possible for overcoming the limitations mentioned above. With self-adjuvant properties, high targeting ability, and good biocompatibility, the inorganic nanomaterials have been integrated with cancer immunotherapy and significantly improved the therapeutic effects.

【 授权许可】

Unknown