Reliability of cerebral autoregulation using different measures of perfusion pressure in patients with subarachnoid hemorrhage

Physiological Reports

Ronan M. G. Berg¹  Markus Harboe Olsen²  Søren Bache²  Kirsten Møller²  Christian Gunge Riberholt²  Tenna Capion³ 

[1] Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital ‐ Rigshospitalet Copenhagen Denmark;Department of Neuroanaesthesiology The Neuroscience Centre Copenhagen University Hospital ‐ Rigshospitalet Copenhagen Denmark;Department of Neurosurgery The Neuroscience Centre Copenhagen University Hospital ‐ Rigshospitalet Copenhagen Denmark;

关键词: autoregulation;    mean flow index;    Mx;    reliability;    transfer function analysis;   

DOI  :  10.14814/phy2.15203

来源: DOAJ

【 摘 要 】

Abstract Dynamic cerebral autoregulation to spontaneous fluctuations in cerebral perfusion pressure (CPP) is often assessed by transcranial Doppler (TCD) in the time domain, yielding primarily the mean flow index (Mx), or in the frequency domain using transfer function analysis (TFA), yielding gain and phase. For both domains, the measurement of blood pressure is critical. This study assessed the inter‐method reliability of dynamic cerebral autoregulation using three different methods of pressure measurement. In 39 patients with aneurysmal subarachnoid hemorrhage, non‐invasive arterial blood pressure (ABP), invasive ABP (measured in the radial artery) and CPP were recorded simultaneously with TCD. Intraclass correlation coefficient (ICC) was used to quantify reliability. Mx was higher when calculated using invasive ABP (0.39; 95% confidence interval [95% CI]: 0.33; 0.44) compared to non‐invasive ABP, and CPP. The overall ICC showed poor to good reliability (0.65; 95% CI: 0.11; 0.84; n = 69). In the low frequency domain, the comparison between invasively measured ABP and CPP showed good to excellent (normalized gain, ICC: 0.87, 95CI: 0.81; 0.91; n = 96; non‐normalized gain: 0.89, 95% CI: 0.84; 0.92; n = 96) and moderate to good reliability (phase, ICC: 0.69, 95% CI: 0.55; 0.79; n = 96), respectively. Different methods for pressure measurement in the assessment of dynamic cerebral autoregulation yield different results and cannot be used interchangeably.

【 授权许可】

Unknown