Novel Gels: An Emerging Approach for Delivering of Therapeutic Molecules and Recent Trends

Gels

Vishal N. Gupta¹  Sharadha Madhusudhan¹  Devegowda V. Gowda¹  Balamuralidhara Veeranna¹  Hitesh Kumar¹  Souvik Chakraborty¹  Vikas Jain¹  Trideva K. Sastri¹  Pallavi Chand¹ 

[1] Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Sri Shivarathreeshwara Nagar, Mysuru 570015, India;

关键词: hydrogels;    in situ gels;    emulsion gels;    microgels;    nanogels;    vesicular gels;   

DOI  :  10.3390/gels8050316

来源: DOAJ

【 摘 要 】

Gels are semisolid, homogeneous systems with continuous or discrete therapeutic molecules in a suitable lipophilic or hydrophilic three-dimensional network base. Innovative gel systems possess multipurpose applications in cosmetics, food, pharmaceuticals, biotechnology, and so forth. Formulating a gel-based delivery system is simple and the delivery system enables the release of loaded therapeutic molecules. Furthermore, it facilitates the delivery of molecules via various routes as these gel-based systems offer proximal surface contact between a loaded therapeutic molecule and an absorption site. In the past decade, researchers have potentially explored and established a significant understanding of gel-based delivery systems for drug delivery. Subsequently, they have enabled the prospects of developing novel gel-based systems that illicit drug release by specific biological or external stimuli, such as temperature, pH, enzymes, ultrasound, antigens, etc. These systems are considered smart gels for their broad applications. This review reflects the significant role of advanced gel-based delivery systems for various therapeutic benefits. This detailed discussion is focused on strategies for the formulation of different novel gel-based systems, as well as it highlights the current research trends of these systems and patented technologies.

【 授权许可】

Unknown