Time-restricted feeding rescues high-fat-diet-induced hippocampal impairment

iScience

Stefani D. Yates¹  Jodi R. Paul¹  Elam J. Cutts¹  Jennifer A. Davis¹  Karen L. Gamble¹  Lori L. McMahon²  Shannon M. Bailey³  Jennifer S. Pollock⁴  David M. Pollock⁴ 

[1] Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 1720 7th Avenue S., Birmingham, AL 35294, USA;School of Medicine, Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA;School of Medicine, Division of Molecular and Cellular Pathology, University of Alabama at Birmingham, Birmingham, AL, USA;School of Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, USA;

关键词: Biological Sciences;    Neuroscience;    Cognitive Neuroscience;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Feeding rodents a high-fat diet (HFD) disrupts normal behavioral rhythms, particularly meal timing. Within the brain, mistimed feeding shifts molecular rhythms in the hippocampus and impairs memory. We hypothesize that altered meal timing induced by an HFD leads to cognitive impairment and that restricting HFD access to the “active period” (i.e., night) rescues the normal hippocampal function. In male mice, ad-lib access to an HFD for 20 weeks increased body weight and fat mass, increased daytime meal consumption, reduced hippocampal long-term potentiation (LTP), and eliminated day/night differences in spatial working memory. Importantly, two weeks of time-restricted feeding (TRF) at the end of the chronic HFD protocol rescued spatial working memory and restored LTP magnitude, even though there was no change in body composition and total daily caloric intake. These findings suggest that short-term TRF is an effective mechanism for rescuing HFD-induced impaired cognition and hippocampal function.

【 授权许可】

Unknown