Opportunistic Detection for Pancreatic Cystic Lesions During Chest Multidetector CT Scans for Lung Cancer Screening

Cancer Management and Research

关键词: pancreatic cystic lesion;    computed tomography;    prevalence;    progression;    chinese population;   

DOI  :  

来源: DOAJ

【 摘 要 】

Xin Chen,1,2,* Zhicheng Yu,1,3,* Jianhua Wang,1 Wenjing Cui,1 Can Cui,1 Yajie Wang,1 Yongkang Liu,1 Hao Zhou,1 Cheng Wang,4 Zhongqiu Wang,1 Xiao Chen1 1Department of Radiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, People’s Republic of China; 2Department of Radiology, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, 200233, People’s Republic of China; 3Department of Radiology, Jiading Central Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, 201800, People’s Republic of China; 4Department of Radiology, Nanjing Drum Tower Hospital the Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhongqiu Wang; Xiao ChenDepartment of Radiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, Nanjing, 210029, People’s Republic of ChinaTel [phone]Email [e-mail]; [e-mail]: The purpose of this study was to analyze the prevalence of and risk factors for incidental pancreatic cystic lesions (PCLs) in the Chinese general population. Furthermore, the association between baseline imaging findings and PCL progression was also investigated.Patients and Methods: A total of 9826 individuals who underwent computed tomography (CT) examinations for lung cancer screening between January 1, 2018 and January 1, 2019 were included in this study. The participants’ CT imaging findings and biochemical biomarker levels were reviewed and analyzed. PCLs detected during the screening were followed up for 12 months. Associations between imaging findings and clinical factors with PCL progression were explored.Results: PCLs were observed in 172 of the 9826 participants. The crude prevalence of PCLs in total population was 1.75%. In subjects aged > 60 years, the prevalence of PCLs was 3.2% (102/3151). The occurrence of PCLs was significantly increased with an increase of age in both men and women (p < 0.001). High-risk PCLsL commonly located in pancreatic head showed extrapancreatic growth, and had high urea levels (p = 0.005, p = 0.015, p = 0.002, respectively) compared with low-risk PCLs. Location in the pancreatic head (odds ratio (OR) = 6.286, 95% confidence interval (CI): 1.842– 21.452) and extrapancreatic growth (OR = 4.049, 95% CI: 1.235– 13.333) were risk factors for PCL progression.Conclusion: PCLs are not uncommon in the Chinese general population. Location in the pancreatic head and extrapancreatic growth are the independent predictors of high-risk of PCLs and PCL progression.Keywords: pancreatic cystic lesion, computed tomography, prevalence, progression, Chinese population

【 授权许可】

Unknown