Prominent Efficacy of Amantadine against Human Borna Disease Virus Infection In Vitro and In Vivo. Comment on Fink et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses 2021, 13, 539

Viruses

Detlef E. Dietrich¹  Carsten W. Spannhuth²  Liv Bode³  Hanns Ludwig³ 

[1] Ameos Clinic Hildesheim Psychotherapy and Psychiatry, 31135 Hildesheim, Germany;Department of Mental Health, Hannover Medical School, 30625 Hanover, Germany;Joint Senior Scientists, Freelance Bornavirus Workgroup, 14163 Berlin, Germany;

关键词: amantadine;    human Borna disease virus;    in vitro;    in vivo;    antiviral;   

DOI  :  10.3390/v14030494

来源: DOAJ

【 摘 要 】

Amantadine (1-amino-adamantane) is a versatile antiviral compound which has been licensed for decades against influenza viruses. During the Corona pandemic, its effect to inhibit SARS-CoV-2 in vitro has been investigated. However, an in vivo oral inapplicability was concluded due to ID₅₀ doses exceeding eight times the estimated maximum tolerable plasma levels reached by 600 mg orally daily. In contrast, amantadine has been shown to be extraordinarily efficient against human neurotropic Borna disease virus (BoDV-1), presenting with both anti-depressive and anti-viral efficacy against a placebo, achieved by a well-tolerated low oral daily dose of 200 mg amantadine.

【 授权许可】

Unknown