Lipid Alterations in Systemic Sclerosis

Frontiers in Molecular Biosciences

Jacek Turyn¹  Zuzanna Gogulska²  Zaneta Smolenska²  Zbigniew Zdrojewski²  Adriana Mika³ 

[1]Department of Biochemistry, Medical University of Gdansk, Gdansk, Poland

[2]Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdansk, Gdansk, Poland

[3]Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, Poland

关键词: metabolomics;    lipidomics;    systemic sclerosis;    biomarkers;    lipids;   

DOI  :  10.3389/fmolb.2021.761721

来源: DOAJ

【 摘 要 】

Background: Systemic sclerosis (SSc) is an autoimmune disease with an elusive etiology and poor prognosis. Due to its diverse clinical presentation, a personalized approach is obligatory and needs to be based on a comprehensive biomarker panel. Therefore, particular metabolomic studies are necessary. Lipidomics addressed these issues and found disturbances in several crucial metabolic pathways.Aim of Review: The review aims to briefly summarize current knowledge related to lipid alterations in systemic sclerosis, highlight its importance, and encourage further research in this field.Key Scientific Concepts of Review: In this review, we summarized the studies on the lipidomic pattern, fatty acids, lipoproteins, cholesterol, eicosanoids, prostaglandins, leukotrienes, lysophospholipids, and sphingolipids in systemic sclerosis. Researchers demonstrated several alternate aspects of lipid metabolism. As we aimed to present our findings in a comprehensive view, we decided to divide our findings into three major groups: “serum lipoproteins,” “fatty acids and derivatives,” and “cellular membrane components,” as we do believe they play a prominent role in SSc pathology.

【 授权许可】

Unknown