A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren’s syndrome

BMC Immunology

Xiaoxia Pan¹  Yuqi Shen¹  Hong Ren¹  Yifan Shi¹  Xiao Li¹  Li Lin¹  Pingyan Shen¹  Jingyuan Xie¹  Yuhua Ma² 

[1] Department of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine;Department of Nephrology, Traditional Chinese Medicine Hospital of KunShan;

关键词: Primary Sjogren’s syndrome;    CD72 expression on B cell;    Serum soluble CD72 level;    Serum IgG level;   

DOI  :  10.1186/s12865-020-00351-2

来源: DOAJ

【 摘 要 】

Abstract Background CD72, a co-receptor of B cell receptor (BCR), has been reported to have both positive and negative effects on B cell functions in several immunological diseases. The B cell plays an important role in the pathogenesis of primary Sjogren’s syndrome (pSS). However, whether CD72 is involved in the process remains unknown. This study aimed to observe the possible role of CD72 in the pathogenesis of pSS. Results A total of 60 cases who fulfilled the American-European Consensus Group (AECG) criteria for the diagnosis of pSS and 61 gender and age-matched healthy controls were recruited in this study. The percentage of CD72+ B cells was 85.31 ± 8.37% in pSS patients and 76.91 ± 8.50% in healthy controls(p < 0.001). The percentage of CD72+ B cells was correlated to serum IgG levels in patients [β = 0.018(0.001–0.036), p = 0.034]. The level of serum soluble CD72 was significantly higher in pSS patients than the one in healthy controls (0.41 (0.29) vs 0.07 (0.08) ng/mL, p < 0.001). Conclusions The percentage of CD72+ B cells was upregulated in pSS patients and was correlated to the serum IgG level, which revealed the hyperactivity of B cells in this disease. The serum soluble CD72 level was also increased in pSS patients. These results indicated a potential role of CD72 in the pathogenesis of pSS.

【 授权许可】

Unknown