Biological Role of Unsaturated Fatty Acid Desaturases in Health and Disease

Nutrients

Aleksandra Czumaj¹  Tomasz Śledziński¹ 

[1] Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, Medical University of Gdansk, Dębinki, 80-211 Gdansk, Poland;

关键词: fatty acid desaturase;    polyunsaturated fatty acid;    desaturation;    disease;    fads;   

DOI  :  10.3390/nu12020356

来源: DOAJ

【 摘 要 】

Polyunsaturated fatty acids (PUFAs) are considered one of the most important components of cells that influence normal development and function of many organisms, both eukaryotes and prokaryotes. Unsaturated fatty acid desaturases play a crucial role in the synthesis of PUFAs, inserting additional unsaturated bonds into the acyl chain. The level of expression and activity of different types of desaturases determines profiles of PUFAs. It is well recognized that qualitative and quantitative changes in the PUFA profile, resulting from alterations in the expression and activity of fatty acid desaturases, are associated with many pathological conditions. Understanding of underlying mechanisms of fatty acid desaturase activity and their functional modification will facilitate the development of novel therapeutic strategies in diseases associated with qualitative and quantitative disorders of PUFA.

【 授权许可】

Unknown