Metastatic colorectal cancer and type 2 diabetes: prognostic and genetic interactions

Molecular Oncology

Giovanni Savarese¹  Luisa Circelli¹  Maurizio Capuozzo²  Angela Lombardi³  Silvia Zappavigna³  Michele Caraglia³  Annabella Di Mauro⁴  Marco Cascella⁴  Francesco Perri⁴  Alessandro Ottaiano⁴  Guglielmo Nasti⁴  Vincenza Granata⁴  Mariachiara Santorsola⁴  Valerio Gigantino⁵  Daniela Fontanella⁵ 

[1] AMES, Centro Polidiagnostico Strumentale srl Naples Italy;Department of Pharmacy ASL‐Naples‐3 Ercolano Italy;Department of Precision Medicine University “L. Vanvitelli” of Naples Italy;Istituto Nazionale Tumori di Napoli, IRCCS “G. Pascale,” Naples Italy;Molecular Biology Innovalab Scarl Naples Italy;

关键词: genes;    metastatic colorectal cancer;    oligo‐metastatic colorectal cancer;    prognosis;    survival;    type 2 diabetes;   

DOI  :  10.1002/1878-0261.13122

来源: DOAJ

【 摘 要 】

The present study was undertaken to analyze prognostic and genetic interactions between type 2 diabetes and metastatic colorectal cancer. Patients’ survival was depicted through the Kaplan–Meier product limit method. Prognostic factors were examined through the Cox proportional‐hazards regression model, and associations between diabetes and clinical‐pathologic variables were evaluated by the χ2 test. In total, 203 metastatic colorectal cancer patients were enrolled. Lymph nodes (P = 0.0004) and distant organs (> 2 distant sites, P = 0.0451) were more frequently involved in diabetic patients compared with those without diabetes. Diabetes had an independent statistically significant negative prognostic value for survival. Highly selected patients with cancer and/or diabetes as their only illness(es) were divided into three groups: (a) seven oligo‐metastatic patients without diabetes, (b) 10 poly‐metastatic patients without diabetes, and (c) 12 poly‐metastatic diabetic patients. These groups of patients were genetically characterized through the Illumina NovaSeq 6000 (San Diego, CA, USA) platform and TruSigt™Oncology 500 kit, focusing on genes involved in diabetes and colorectal cancer. Gene variants associated with diabetes and cancer were more frequent in patients in group 3. We found that type 2 diabetes is a negative prognostic factor for survival in colorectal cancer. Diabetes‐associated gene variants could concur with malignancy, providing a rational basis for innovative models of tumor progression and therapy.

【 授权许可】

Unknown