Synthesis of Hydroxyapatite/Ag/TiO2 Nanotubes and Evaluation of Their Anticancer Activity on Breast Cancer Cell Line MCF-7

Journal of Chemical Health Risks

Maryam Bikhof Torbati¹  Sara Rahimnejad² 

[1] Department of Biology, College of Basic Science, Yadegar-e-Imam Khomeini(RAH) Shahre Rey Branch, Islamic Azad University, Tehran, Iran;Department of Chemistry, College of Basic science, Yadegar-e-Imam Khomeini (RAH( Shahre Rey Branch, Islamic Azad University, Tehran, Iran;

关键词: Hydroxyapatite;    Nanotube;    TiO2;    Anticancer;    Breast cancer;    MCF-7;   

DOI  :  

来源: DOAJ

【 摘 要 】

In this research, TiO₂ nanotubes were synthesized by anodized oxidation method and were covered with a hydroxyapatite-silver nanoparticles using photodeposition and dip coating for loading silver nanoparticles and coated hydroxyapatite (HA). The morphological texture of TiO₂ nanotube and Ag-HA nanoparticles on TiO₂ nanotubes surface were studied by field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDAX analysis) and X-ray diffraction (XRD). The MCF-7 cell lines were treated with concentrations 1, 10 and 100 µg/ml of TiO₂ nanotubes and HA/Ag/TiO₂ nanotube for 24 and 48h. Finally, the cell viability and IC50% were evaluated using MTT assay. The results show that the HA/Ag/TiO₂ has more positive effect on enhancing the cell death compare to TiO₂ nanotubes and also exerts a time and concentration-dependent inhibition effect on viability of MCF-7 cells

【 授权许可】

Unknown