Tribbles homolog 2 (Trib2), a pseudo serine/threonine kinase in tumorigenesis and stem cell fate decisions

Cell Communication and Signaling

Yu Fang¹  Farhoodeh Ghaedrahmati²  Angelina Olegovna Zekiy³  Amir Anbiyaiee⁴  Maryam Farzaneh⁵  Anton Timoshin⁶  Seyed Esmaeil Khoshnam⁷ 

[1] Anyang Center for Chemical and Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Anyang Normal University;Department of Immunology, School of Medicine, Isfahan University of Medical Sciences;Department of Prosthetic Dentistry, Sechenov First Moscow State Medical University;Department of Surgery, School of Medicine, Ahvaz Jundishapur University of Medical Sciences;Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences;Independent researcher;Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences;

关键词: Pluripotent stem cells;    Tribbles homolog 2;    Tumorigenesis;    Pluripotency;    Reprogramming;    Stem cell fate;   

DOI  :  10.1186/s12964-021-00725-y

来源: DOAJ

【 摘 要 】

Abstract The family of Tribbles proteins play many critical nonenzymatic roles and regulate a wide range of key signaling pathways. Tribbles homolog 2 (Trib2) is a pseudo serine/threonine kinase that functions as a scaffold or adaptor in various physiological and pathological processes. Trib2 can interact with E3 ubiquitin ligases and control protein stability of downstream effectors. This protein is induced by mitogens and enhances the propagation of several cancer cells, including myeloid leukemia, liver, lung, skin, bone, brain, and pancreatic. Thus, Trib2 can be a predictive and valuable biomarker for the diagnosis and treatment of cancer. Recent studies have illustrated that Trib2 plays a major role in cell fate determination of stem cells. Stem cells have the capacity to self-renew and differentiate into specific cell types. Stem cells are important sources for cell-based regenerative medicine and drug screening. Trib2 has been found to increase the self-renewal ability of embryonic stem cells, the reprogramming efficiency of somatic cells, and chondrogenesis. In this review, we will focus on the recent advances of Trib2 function in tumorigenesis and stem cell fate decisions. Video abstract

【 授权许可】

Unknown