Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules

Cancers

Atsuhiro Shimizu¹  Yusuke Matsuno¹  Mai Hyodo¹  Haruka Fujimori¹  Ken-ichi Yoshioka¹ 

[1] Division of Carcinogenesis and Cancer Prevention, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan;

关键词: chemotherapy;    anticancer drug;    camptothecin;    PARP inhibitor;    radiotherapy;    sensitizer;    DNA repair;    apoptosis;    checkpoint response;   

DOI  :  10.3390/cancers10100364

来源: DOAJ

【 摘 要 】

Radiation and certain anticancer drugs damage DNA, resulting in apoptosis induction in cancer cells. Currently, the major limitations on the efficacy of such therapies are development of resistance and adverse side effects. Sensitization is an important strategy for increasing therapeutic efficacy while minimizing adverse effects. In this manuscript, we review possible sensitization strategies for radiation and anticancer drugs that cause DNA damage, focusing especially on modulation of damage repair pathways and the associated reactions.

【 授权许可】

Unknown