期刊论文详细信息
OncoImmunology | |
Metabolism in the tumor microenvironment: insights from single-cell analysis | |
Zhengtao Xiao1  Ziwei Dai1  Jason W. Locasale2  | |
[1] Duke University School of Medicine;Mainline Station Drive; | |
关键词: cancer metabolism; immunometabolism; tumor microenvironment; single-cell rna sequencing; | |
DOI : 10.1080/2162402X.2020.1726556 | |
来源: DOAJ |
【 摘 要 】
The metabolism of both cancer and immune cells in the tumor microenvironment (TME) is poorly understood since most studies have focused on analysis in bulk samples and ex vivo cell culture models. Our recent analyses of single-cell RNA sequencing data suggest that the metabolic features of single cells within TME differ greatly from those of the bulk measurements. Here, we discuss some key findings about metabolism in cancer and immune cells and discuss possible relevance to immunotherapy.
【 授权许可】
Unknown