Focal neuroendocrine differentiation in prostatic gland carcinoma with basaloid pattern

Vojnosanitetski Pregled

关键词: prostatic neoplasms;    prostatic hyperplasia;    antigens, differentiation;    histological techniques;    immunohistochemistry;   

DOI  :  10.2298/VSP1106515G

来源: DOAJ

【 摘 要 】

Introduction. Prostatic gland basal cell proliferations exhibit morphologicalcontinuum ranging from basal cell hyperplasia to basal cell carcinoma. In thefollowing report, we described clinical features, morphological spectrum,neuroendocrine differentiation and histogenesis of prostatic gland basal cellcarcinoma in our patient. Case report. Hematoxylineosin (HE), Alcianblu-periodic acid schiff (ABPAS) at pH 2.5 stained sections and theavidin-biotinperoxidase complex (ABC), were performed on prostate glandparaffin-embedded tissue. Monoclonal antibodies directed against cytokeratin(34βE12) which selectively stains basal cells, prostate specific antigen(PSA), chromogranine A, neuron-specific enolase (NSE), synaptophysin andCD56, were used. Basal cell proliferations exhibited a morphologicalcontinuum ranging from basal cell hyperplasia to prostatic gland carcinoma.In these prostatic lesions, positive reactivity was demonstrated for 34βE12and CD56. These findings indicate that the basaloid cells of basal cellhyperplasia, florid basal cell hyperplasia, atypical basal cell hyperplasiaand basal cell carcinoma are derived from basal cells of the normal prostategland suggesting a continuum in the progression of hyperplasia to benign andthen malignant neoplasia. The presence of CD56 protein in the discoveredlesions may be related to their neuroendocrine differentiation. Conclusion.The fact, that our patient was well six years after the radical prostatectomysupports the belief of some authors that basal cell carcinoma represents alow grade carcinoma with an excellent prognosis.

【 授权许可】

Unknown