Host Lipids in Positive-Strand RNA Virus Genome Replication

Frontiers in Microbiology

Benjamin G. Kopek¹  Natalie A. Filipowicz¹  Glenn Randall²  Guijuan He³  Xiaofeng Wang⁵  Zhenlu Zhang⁵  George A. Belov⁶ 

[1] Department of Biology, Hope College, Holland, MI, United States;Department of Microbiology, The University of Chicago, Chicago, IL, United States;Fujian Province Key Laboratory of Plant Virology, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, China;National Key Laboratory of Crop Biology, National Research Center for Apple Engineering and Technology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, China;School of Plant and Environmental Sciences, Virginia Tech, Blacksburg, VA, United States;Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, United States;

关键词: lipid metabolism;    phospholipids;    membrane association;    positive-strand RNA virus;    viral RNA replication;   

DOI  :  10.3389/fmicb.2019.00286

来源: DOAJ

【 摘 要 】

Membrane association is a hallmark of the genome replication of positive-strand RNA viruses [(+)RNA viruses]. All well-studied (+)RNA viruses remodel host membranes and lipid metabolism through orchestrated virus-host interactions to create a suitable microenvironment to survive and thrive in host cells. Recent research has shown that host lipids, as major components of cellular membranes, play key roles in the replication of multiple (+)RNA viruses. This review focuses on how (+)RNA viruses manipulate host lipid synthesis and metabolism to facilitate their genomic RNA replication, and how interference with the cellular lipid metabolism affects viral replication.

【 授权许可】

Unknown