The roles of vitamin D and cathelicidin in type 1 diabetes susceptibility

Endocrine Connections

Alexandra Machado¹  Bruno Sarmento²  Cecília Cristelo³  Francisco Miguel Gama³ 

[1] CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal;CEB – Centro de Engenharia Biológica, Universidade do Minho, Braga, Portugal;i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal;

关键词: β cell protection;    cathelicidin;    diabetes;    immunomodulation;    vitamin d;   

DOI  :  https://doi.org/10.1530/EC-20-0484

来源: DOAJ

【 摘 要 】

Type 1 diabetes has an increasingly greater incidence and prevalence with no cure available. Vitamin D supplementation is well documented to reduce the risk of developing type 1 diabetes. Being involved in the modulation of cathelicidin expression, the question whether cathelicidin may be one of the underlying cause arises. Cathelicidin has been implicated in both the development and the protection against type 1 diabetes by mediating the interplay between the gut microbiome, the immune system and β cell function. While its potential on type 1 diabetes treatment seems high, the understanding of its effects is still limited. This review aims to contribute to a more comprehensive understanding of the potential of vitamin D and cathelicidin as adjuvants in type 1 diabetes therapy.

【 授权许可】

Unknown