Remote cortical perturbation dynamically changes the network solutions to given tactile inputs in neocortical neurons

iScience

Jonas M.D. Enander¹  Leila Etemadi²  Henrik Jörntell² 

[1] Corresponding author;Neural Basis of Sensorimotor Control, Department of Experimental Medical Science, Lund University, BMC F10 Tornavägen 10, 221 84 Lund, Sweden;

关键词: Neuroscience;    Cellular neuroscience;    Sensory neuroscience;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: The neocortex has a globally encompassing network structure, which for each given input constrains the possible combinations of neuronal activations across it. Hence, its network contains solutions. But in addition, the cortex has an ever-changing multidimensional internal state, causing each given input to result in a wide range of specific neuronal activations. Here we use intracellular recordings in somatosensory cortex (SI) neurons of anesthetized rats to show that remote, subthreshold intracortical electrical perturbation can impact such constraints on the responses to a set of spatiotemporal tactile input patterns. Whereas each given input pattern normally induces a wide set of preferred response states, when combined with cortical perturbation response states that did not otherwise occur were induced and consequently made other response states less likely. The findings indicate that the physiological network structure can dynamically change as the state of any given cortical region changes, thereby enabling a rich, multifactorial, perceptual capability.

【 授权许可】

Unknown