Undifferentiated Pancreatic Carcinoma With Osteoclast-Like Giant Cells: What Do We Know So Far?

Frontiers in Oncology

Jean-Luc Van Laethem¹  Myriam Delhaye¹  Sébastien Debroux²  Raphaël Maréchal²  Francesco Puleo³  Laurine Verset⁴  Pieter Demetter⁴  Maria Gomez Galdon⁴  Fadi Charara⁵ 

[1]Department of Gastroenterology and Digestive Oncology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium

[2]Department of Gastroenterology, CHU Tivoli, La Louvière, Belgium

[3]Department of Gastroenterology, Hôpital Delta, Brussels, Belgium

[4]Department of Pathology, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium

[5]Department of Surgery, CHU Tivoli, La Louvière, Belgium

关键词: undifferentiated (anaplastic) carcinoma;    pancreas;    osteoclast-like giant cells;    pancreatic ductal adenocarcinoma;    adenocarcinoma;   

DOI  :  10.3389/fonc.2021.630086

来源: DOAJ

【 摘 要 】

Undifferentiated carcinoma of the pancreas is an aggressive but rare tumor for which several other terms have been used to describe its histological appearance. In addition, as osteoclast-like giant cells may accompany undifferentiated carcinoma of the pancreas, the WHO Classification distinguishes undifferentiated carcinoma with osteoclast-like giant cells (UC-OGC) from plain undifferentiated carcinoma since there are a few histopathological and clinical differences. UC-OGC was initially thought to be associated with worse prognosis compared to invasive ductal pancreatic adenocarcinoma, since it is often unresectable at diagnosis and tends to recur rapidly even if completely resected. When true UC-OGGs are carefully dissected out from other anaplastic carcinomas, it becomes, however, clear that UC-OGCs do have more indolent behavior, especially the pure UC-OGCs. This mini-review summarizes the current knowledge on UC-OGC.

【 授权许可】

Unknown