Spray Drying for the Preparation of Nanoparticle-Based Drug Formulations as Dry Powders for Inhalation

Processes

Anastasia Charisi¹  Kyriakos Kachrimanis¹  Ioannis Nikolakakis¹  Stavros Malamataris¹  Maria Malamatari² 

[1] Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece;Department of Pharmaceutics, UCL School of Pharmacy, 29–39 Brunswick Square, London WC1N 1AX, UK;

关键词: drug nanoparticles;    dry powder inhalers;    nanoparticle agglomerates;    pulmonary drug delivery;    spray drying;   

DOI  :  10.3390/pr8070788

来源: DOAJ

【 摘 要 】

Nanoparticle-based therapeutics have been used in pulmonary formulations to enhance delivery of poorly water-soluble drugs, protect drugs against degradation and achieve modified release and drug targeting. This review focuses on the use of spray drying as a solidification technique to produce microparticles containing nanoparticles (i.e., nanoparticle (NP) agglomerates) with suitable properties as dry powders for inhalation. The review covers the general aspects of pulmonary drug delivery with emphasis on nanoparticle-based dry powders for inhalation and the principles of spray drying as a method for the conversion of nanosuspensions to microparticles. The production and therapeutic applications of the following types of NP agglomerates are presented: nanoporous microparticles, nanocrystalline agglomerates, lipid-based and polymeric formulations. The use of alternative spray-drying techniques, namely nano spray drying, and supercritical CO₂-assisted spray drying is also discussed as a way to produce inhalable NP agglomerates.

【 授权许可】

Unknown