Inter-Session Reliability of Functional Near-Infrared Spectroscopy at the Prefrontal Cortex While Walking in Multiple Sclerosis

Brain Sciences

Kim-Charline Broscheid¹  Lutz Schega¹  Dennis Hamacher¹  Michael Sailer²  Juliane Lamprecht² 

[1] Department of Sport Science, Institute III, Otto von Guericke University (OvGU) Magdeburg, Zschokkestraße 32, 39104 Magdeburg, Germany;MEDIAN Neurological Rehabilitation Center Magdeburg, Gustav-Ricker-Straße 4, 39120 Magdeburg, Germany;

关键词: MS;    hemodynamic response;    fNIRS;    test–retest reliability;    cortical activity;    PFC;   

DOI  :  10.3390/brainsci10090643

来源: DOAJ

【 摘 要 】

Many established technologies are limited in analyzing the executive functions in motion, especially while walking. Functional near-infrared spectroscopy (fNIRS) fills this gap. The aim of the study is to investigate the inter-session reliability (ISR) of fNIRS-derived parameters at the prefrontal cortex while walking in people with multiple sclerosis (MS) and healthy control (HC) individuals. Twenty people with MS/HC individuals walked a 12 m track back and forth over 6 min. The primary outcomes were the absolute and relative reliability of the mean, slope coefficient (SC), and area under the curve (A) of the oxy-/deoxyhemoglobin concentrations (HbO/HbR) in the Brodmann areas (BA) 9/46/10. The SC and the A of HbO exhibited a fair ISR in BA10 in people with MS. For the mean and A of the HbR, almost all areas observed revealed a fair ISR. Overall, the ISR was better for HbR than HbO. A fair to excellent ISR was found for most BA of the prefrontal cortex in HC individuals. In total, the ISR of the analyzed fNIRS-derived parameters was limited. To improve the ISR, confounders such as fatigue and mind wandering should be minimized. When reporting the ISR, the focus should be on the mean/A rather than SC.

【 授权许可】

Unknown