Lesões em DNA induzidas pela autoxidação de S(IV) na presença de íons metálicos de transição

Química Nova

Nina Coichev¹  Ruben G. M. Moreno¹  Marisa H. G. Medeiros¹  María V. Alipázaga¹ 

[1] Universidade de São Paulo;

关键词: DNA cleavage;    oxysulfur radical;    transition metal ions;   

DOI  :  10.1590/S0100-40422006000500032

来源: DOAJ

【 摘 要 】

The oxidation of sulfite catalyzed by transition metal ions produces reactive oxysulfur species that can damage plasmid and isolated DNA in vitro. Among the four DNA bases, guanine is the most sensitive to one-electron oxidation promoted by the species formed in the autoxidation of sulfite (HSO5-, HO•, SO3•-, SO4•- and SO5•-) due to its low reduction potential and ability to bind transition metal ions capable to catalyze oxidative processes. Some oxidative DNA lesions are promutagenic and oxidative DNA damage is proposed to play a crucial role in certain human pathologies, including cancer.

【 授权许可】

Unknown