Exploitation of the Host Ubiquitin System: Means by Legionella pneumophila

Frontiers in Microbiology

Zhao-Qing Luo¹  Lei Song²  Jingjing Luo²  Lidong Wang² 

[1] Department of Biological Sciences, Purdue University, West Lafayette, IN, United States;Department of Respiratory Medicine, Center for Pathogen Biology and Infectious Diseases, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China;

关键词: ubiquitin;    intracellular pathogen;    effector;    immunity;    virulence;   

DOI  :  10.3389/fmicb.2021.790442

来源: DOAJ

【 摘 要 】

Ubiquitination is a commonly used post-translational modification (PTM) in eukaryotic cells, which regulates a wide variety of cellular processes, such as differentiation, apoptosis, cell cycle, and immunity. Because of its essential role in immunity, the ubiquitin network is a common target of infectious agents, which have evolved various effective strategies to hijack and co-opt ubiquitin signaling for their benefit. The intracellular pathogen Legionella pneumophila represents one such example; it utilizes a large cohort of virulence factors called effectors to modulate diverse cellular processes, resulting in the formation a compartment called the Legionella-containing vacuole (LCV) that supports its replication. Many of these effectors function to re-orchestrate ubiquitin signaling with distinct biochemical activities. In this review, we highlight recent progress in the mechanism of action of L. pneumophila effectors involved in ubiquitination and discuss their roles in bacterial virulence and host cell biology.

【 授权许可】

Unknown