Relationship between Muscle Mass and Non-Alcoholic Fatty Liver Disease

Biology

Hye-Sun Lee¹  Ji-Won Lee²  Yu-Jin Kwon³  Byoung-Kwon Lee⁴  Jun-Hyuk Lee⁵ 

[1] Biostatistics Collaboration Unit, Department of Research Affairs, Yonsei University College of Medicine, Seoul 06273, Korea;Department of Family Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul 06273, Korea;Department of Family Medicine, Yonsei University College of Medicine, Yongin Severance Hospital, Yongin 16995, Korea;Department of Internal Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul 06273, Korea;Department of Medicine, Graduate School of Yonsei University College of Medicine, Seoul 03722, Korea;

关键词: sarcopenia;    non-alcoholic fatty liver disease;    obesity;    skeletal muscle mass;    inflammation;   

DOI  :  10.3390/biology10020122

来源: DOAJ

【 摘 要 】

Although sarcopenia is known to be a risk factor for non-alcoholic fatty liver disease (NAFLD), whether NAFLD is a risk factor for the development of sarcopenia is not clear. We investigated relationships between NAFLD and low skeletal muscle mass index (LSMI) using three different datasets. Participants were classified into LSMI and normal groups. LSMI was defined as a body mass index (BMI)-adjusted appendicular skeletal muscle mass <0.789 in men and <0.512 in women or as the sex-specific lowest quintile of BMI-adjusted total skeletal muscle mass. NAFLD was determined according to NAFLD liver fat score or abdominal ultrasonography. The NAFLD groups showed a higher hazard ratios (HRs) with 95% confidence intervals (CIs) for LSMI than the normal groups (HRs = 1.21, 95% CIs = 1.05–1.40). The LSMI groups also showed a higher HRs with 95% CIs for NAFLD than normal groups (HRs = 1.56, 95% CIs = 1.38–1.78). Participants with NAFLD had consistently less skeletal muscle mass over 12 years of follow-up. In conclusion, LSMI and NAFLD showed a relationship. Maintaining muscle mass should be emphasized in the management of NAFLD.

【 授权许可】

Unknown