ESTRO/ACROP IORT recommendations for intraoperative radiation therapy in primary locally advanced rectal cancer

Clinical and Translational Radiation Oncology

Philip Poortmans¹  Falk Roeder²  Harm J. Rutten³  Javier Serrano³  Claudio V. Sole⁴  Felipe A. Calvo⁵  Jose M. Asencio⁶  Javier Aristu⁷  Wim J Dries⁸ 

[1] Corresponding author at: Department of Oncology, Clínica Universidad de Navarra, Madrid, Spain.;GROW: School of Oncology and Developmental Biology, University of Maastricht, Maastricht, the Netherlands;Institute for Sanitary Research, Hospital General Universitario Gregorio Marañón, Madrid, Spain;School of Medicine, Complutense University, Madrid, Spain;Department of Oncology, Clínica Universidad de Navarra, Madrid, Spain;Department of Radiation Oncology, Instituto de Radiomedicina, Santiago, Chile;Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands;Iridium Kankernetwerk, Oosterveldlaan 22, 2610 Wilrijk-Antwerp, Belgium;

关键词: Rectal cancer;    Locally advanced disease;    Intraoperative radiotherapy;    Radical surgery;    Electron beam;    Neoadjuvant treatment;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Carcinoma of the rectum is a heterogeneous disease. The clinical spectrum identifies a subset of patients with locally advanced tumours that are close to or involve adjoining structures, such as the sacrum, pelvic sidewalls, prostate or bladder. Within this group of patients categorized as “locally advanced”, there is also variability in the extent of disease with no uniform definition of resectability. A practice-oriented definition of a locally advanced tumour is a tumour that cannot be resected without leaving microscopic or gross residual disease at the resection site. Since these patients do poorly with surgery alone, irradiation and chemotherapy have been added to improve the outcome. Intraoperative irradiation (IORT) is a component of local treatment intensification with favourable results in this subgroup of patients.International guidelines (National Comprehensive Cancer Network (NCCN) guidelines) currently recommend the use of IORT for rectal cancer resectable with very close or positive margins, especially for T4 and recurrent cancers.We report the ESTRO-ACROP (European Society for Radiotherapy and Oncology - Advisory Committee on Radiation Oncology Practice) recommendations for performing IORT in primary locally advanced rectal cancer.

【 授权许可】

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