Responsivity of the Striatal Dopamine System to Methylphenidate—A Within-Subject I-123-β-CIT-SPECT Study in Male Children and Adolescents With Attention-Deficit/Hyperactivity Disorder

Frontiers in Psychiatry

Marta Andreatta¹  Susanne Walitza²  Manfred Gerlach³  Marcel Romanos³  Hans-Christoph Aster⁵  Andreas K. Buck⁶  Christoph Reiners⁶  Kai Nerlich⁶  Reinhard Lorenz⁶  Natalie Hasenauer⁶  Philipp E. Hartrampf⁶  Albert Rizzo⁷  Lorenz Deserno⁸  Andreas Mühlberger⁹ 

[1] Clinical Psychology, Erasmus School of Social and Behavioural Sciences, Rotterdam, Netherlands;Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland;Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University of Würzburg, Würzburg, Germany;Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany;Department of Neurology, University of Würzburg, Würzburg, Germany;Department of Nuclear Medicine, University of Würzburg, Würzburg, Germany;Department of Psychiatry and Behavioral Sciences, University of Southern California (USC) Davis School of Gerontology and USC Keck School of Medicine, University of Southern California, Los Angeles, CA, United States;Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany;Department of Psychology, Clinical Psychology and Psychotherapy, University of Regensburg, Regensburg, Germany;

关键词: methylphenidate;    attention deficit/hyperactivity disorder (ADHD);    striatum;    single photon emission computed tomography (SPECT);    responsivity;    caudate nucleus;   

DOI  :  10.3389/fpsyt.2022.804730

来源: DOAJ

【 摘 要 】

Background:Methylphenidate (MPH) is the first-line pharmacological treatment of attention-deficit/hyperactivity disorder (ADHD). MPH binds to the dopamine (DA) transporter (DAT), which has high density in the striatum. Assessments of the striatal dopamine transporter by single positron emission computed tomography (SPECT) in childhood and adolescent patients are rare but can provide insight on how the effects of MPH affect DAT availability. The aim of our within-subject study was to investigate the effect of MPH on DAT availability and how responsivity to MPH in DAT availability is linked to clinical symptoms and cognitive functioning.MethodsThirteen adolescent male patients (9–16 years) with a diagnosis of ADHD according to the DSM-IV and long-term stimulant medication (for at least 6 months) with MPH were assessed twice within 7 days using SPECT after application of I-123-β-CIT to examine DAT binding potential (DAT BP). SPECT measures took place in an on- and off-MPH status balanced for order across participants. A virtual reality continuous performance test was performed at each time point. Further clinical symptoms were assessed for baseline off-MPH.ResultsOn-MPH status was associated with a highly significant change (−29.9%) of striatal DAT BP as compared to off-MPH (t = −4.12, p = 0.002). A more pronounced change in striatal DAT BP was associated with higher off-MPH attentional and externalizing symptom ratings (Pearson r = 0.68, p = 0.01). Striatal DAT BP off-MPH, but not on-MPH, was associated with higher symptom ratings (Pearson r = 0.56, p = 0.04).ConclusionOur findings corroborate previous reports from mainly adult samples that MPH changes striatal DAT BP availability and suggest higher off-MPH DAT BP, likely reflecting low baseline DA levels, as a marker of symptom severity.

【 授权许可】

Unknown