Prognostic Power of Pulmonary Arterial Compliance Is Boosted by a Hemodynamic Unloading Test With Glyceryl Trinitrate in Heart Failure Patients With Post-capillary Pulmonary Hypertension

Frontiers in Cardiovascular Medicine

Stephan Rosenkranz¹  Georgios Zarogiannis²  Ulrich Krüger²  Christian W. Hamm⁴  Dimitri Grün⁴  Till Keller⁴  Manuel J. Richter⁵  Khodr Tello⁵  Andreas J. Rieth⁷  Steffen D. Kriechbaum⁷  Sebastian Wolter⁷  Veselin Mitrovic⁷ 

[1] Clinic III for Internal Medicine, Department of Cardiology, Heart Center at the University of Cologne and Cologne Cardiovascular Research Center (CCRC), University of Cologne, Cologne, Germany;Department of Cardiology, Evangelisches Klinikum Niederrhein, Duisburg, Germany;Department of Cardiology, Kerckhoff-Klinik, Bad Nauheim, Germany;Department of Internal Medicine I, Cardiology, Justus-Liebig-University Giessen, Giessen, Germany;Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Member of the German Center for Lung Research (DZL), Justus Liebig University Giessen, Giessen, Germany;Department of Pneumology, Kerckhoff-Klinik, Bad Nauheim, Germany;German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt am Main, Germany;

关键词: pulmonary arterial compliance;    glyceryl trinitrate (GTN);    vasoreactivity testing;    post-capillary pulmonary hypertension;    hemodynamics;    prognosis;   

DOI  :  10.3389/fcvm.2022.838898

来源: DOAJ

【 摘 要 】

BackgroundPulmonary hypertension (PH) is an established risk factor in patients with heart failure (HF). However, right heart catheterisation (RHC) and vasoreactivity testing (VRT) are not routinely recommended in these patients.MethodsThe primary objective of the present study was to explore the impact of VRT using sublingual glyceryl trinitrate (GTN) on transplant/ventricular assist device-free survival in HF patients with post-capillary PH. RHC parameters were correlated retrospectively with the primary outcome.ResultsThe cohort comprised 154 HF patients with post-capillary PH undergoing RHC with GTN-VRT at a tertiary heart failure centre. Multiple parameters were associated with survival. After adjustment for established prognosis-relevant clinical variables from the MAGGIC Score, variables with the most relevant odds ratios (OR) obtained after GTN-VRT were: calculated effective pulmonary arterial (PA) elastance (adjusted OR 2.26, 95%CI 1.30–3.92; p = 0.004), PA compliance (PAC-GTN; adjusted OR 0.45, 95%CI 0.25–0.80; p = 0.006), and total pulmonary resistance (adjusted OR 2.29, 95%CI 1.34–3.93; p = 0.003). Forest plot analysis including these three variables as well as PAC at baseline, delta PAC, and the presence of combined post- and pre-capillary PH revealed prognostic superiority of PAC-GTN, which was confirmed by Kaplan-Meier analysis.ConclusionsIn our cohort of symptomatic HF patients with post-capillary PH, improved PAC after administration of GTN was associated with survival independent of established hemodynamic and clinical risk factors. VRT using GTN may be better described as unloading test due to GTN's complex effects on the circulation. This could be used for advanced prognostication and should be investigated in further studies.

【 授权许可】

Unknown