GABA signaling stimulates α-cell-mediated β-like cell neogenesis

Communicative & Integrative Biology

Ahmed Mansouri¹  Sergi Navarro Sanz²  Serena Silvano²  Nouha Ben-Othman²  Monica Courtney²  Andhira Vieira²  Patrick Collombat²  Tiziana Napolitano²  Fabio Avolio²  Biljana Hadzic²  Elisabet Gjernes²  Noémie Druelle² 

[1] Max-Planck Institute for Biophysical Chemistry, Department of Molecular Developmental Biology;Université Côte d'Azur, CNRS, Inserm, iBV;

关键词: Arx;    β-cell regeneration;    diabetes;    GABA;    Pax4;   

DOI  :  10.1080/19420889.2017.1300215

来源: DOAJ

【 摘 要 】

Diabetes is a chronic and progressing disease, the number of patients increasing exponentially, especially in industrialized countries. Regenerating lost insulin-producing cells would represent a promising therapeutic alternative for most diabetic patients. To this end, using the mouse as a model, we reported that GABA, a food supplement, could induce insulin-producing beta-like cell neogenesis offering an attractive and innovative approach for diabetes therapeutics.

【 授权许可】

Unknown