Clinical and radiographic evaluation of applying 1% metformin biofilm with plasma rich in growth factor (PRGF) for treatment of two-wall intrabony periodontal defects: A randomized clinical trial

Journal of Dental Research, Dental Clinics, Dental Prospects

Sohrab Kazemi¹  Niloofar Jenabian²  Mahmoud Hajiahmadi³  Sina Haghanifar⁴  Shabnam Khalifehzadeh⁵ 

[1] Cellular and Molecular Biology Research Center Institute, Babol University of Medical Sciences, Babol, Iran;Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran;Department Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran;Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran;Student Research Committee, Babol University of Medical Sciences, Babol, Iran;

关键词: Intrabony two-wall periodontal defects;    Metformin 1%;    plasma rich in growth factor;    regeneration;   

DOI  :  10.15171/joddd.2019.008

来源: DOAJ

【 摘 要 】

Background. The ultimate aim of periodontal treatment is to regenerate periodontium and regenerative treatment after that. The aim of this study was to evaluate the effect of PRGF with 1% metformin biofilm in the treatment of two-wall intrabony periodontal defects.Methods. In this clinical trial, 8 patients with moderate chronic periodontitis and two-wall intrabony defect were selected. The defects were assigned to 4 groups: debridement, 1% metformin, PRGF, PRGF and metformin. The parameters of vertical probing depth, vertical clinical attachment level and gingival index were measured at baseline, immediately before surgery, and 3 and 6 months after surgery. In addition, the radiographic changes were evaluated with digital subtraction radiography before and 6 months after surgery. Analysis of the results was performed with repeated measurements, Friedman test and chisquared test.Results. All the groups exhibited improvements in all the clinical parameters after 6 months. Inter-group comparison of GI, CAL and PPD parameters revealed no statistically significant differences. Radiographic changes in the group of 1% metformin with PRGF revealed statistically significant differences compared with other groups; however, there were no statistically significant differences in other groups.Conclusion. Application of PRGF with 1% metformin in intrabony two-wall periodontal defects was effective in improving the clinical parameters but this effect revealed no difference compared with other groups; however, in terms of radiographic changes significant improvements were noted

【 授权许可】

Unknown