Acute kidney injury in hospitalized cirrhotic patients: Risk factors, type of kidney injury, and survival

JGH Open

Gautam Nath¹  Chitta Ranjan Khatua¹  Shivaram Prasad Singh¹  Saroj Kanta Sahu¹  Dinesh Meher¹ 

[1] Department of Gastroenterology Sriram Chandra Bhanja Medical College and Hospital Cuttack India;

关键词: acute kidney injury;    acute‐on‐chronic liver failure;    chronic liver disease;    decompensated cirrhosis;   

DOI  :  10.1002/jgh3.12467

来源: DOAJ

【 摘 要 】

Abstract Background and Aim Acute kidney injury (AKI) is a common complication of chronic liver disease (CLD). We performed a prospective study to evaluate the risk factors and spectrum of AKI among decompensated cirrhosis (DC) patients and the impact of AKI on survival. Methods This study was conducted in consecutive DC patients hospitalized in SCB Medical College between December 2016 and October 2018. AKI was defined as per ICA criteria. Demographic, clinical, and laboratory parameters and outcomes were compared between patients with and without AKI. Results A total of 576 DC subjects were enrolled, 315 (54.69%) of whom had AKI; 34% (n = 106) had stage 1A, 28% (n = 90) stage 1B, 21% (n = 65) stage 2, and 17% (n = 54) stage 3 AKI. Alcohol was the predominant cause of CLD (66.7%). In 207 (65.7%) patients, diuretic/lactulose/nonsteroidal anti‐inflammatory drugs use was noted, and infection was present in 190 (60.3%) patients. Compared to those without AKI, patients with AKI had higher leucocyte count, higher serum urea and creatinine, higher Child‐Turcotte‐Pugh, higher Model of End‐Stage Liver Disease (MELD) scores (P < 0.001), longer hospital stay, and lower survival at 28 days and 90 days (P < 0.001). Besides, in patients with stages 1A to 3 AKI, there were differences in overall survival at 28 days (P < 0.001) and 90 days (P < 0.001). Conclusions Over half of DC patients had AKI, and alcohol was the most common cause of cirrhosis in them. Use of AKI‐precipitating medications was the most common cause of AKI, followed by bacterial infection. AKI patients had increased prevalence of acute‐on‐chronic liver failure and had prolonged hospitalization and lower survival both at 28 days and 90 days.

【 授权许可】

Unknown