Asymmetric Cell Division and Tumor Heterogeneity

Frontiers in Cell and Developmental Biology

Ying Yi Zhang¹  Yongze Chen²  Haomiao Zhang⁴  Jiaxuan Yang⁵  Zizhu Li⁶  Hezhe Lu⁶ 

[1] Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada;College of Biological Sciences, China Agricultural University, Beijing, China;Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China;School of Stomatology, Dalian Medical University, Dalian, China;State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China;University of Chinese Academy of Sciences, Beijing, China;

关键词: asymmetric cell division;    tumorgenesis;    drug resisitance;    symmetric cell division;    tumor heterogeneity;   

DOI  :  10.3389/fcell.2022.938685

来源: DOAJ

【 摘 要 】

Asymmetric cell division (ACD) gives rise to two daughter cells with different fates after mitosis and is a fundamental process for generating cell diversity and for the maintenance of the stem cell population. The cancer stem cell (CSC) theory suggests that CSCs with dysregulated self-renewal and asymmetric cell division serve as a source of intra-tumoral heterogeneity. This heterogeneity complicates the diagnosis and treatment of cancer patients, because CSCs can give rise to aggressive clones that are metastatic and insensitive to multiple drugs, or to dormant tumor cells that are difficult to detect. Here, we review the regulatory mechanisms and biological significance of asymmetric division in tumor cells, with a focus on ACD-induced tumor heterogeneity in early tumorigenesis and cancer progression. We will also discuss how dissecting the relationship between ACD and cancer may help us find new approaches for combatting this heterogeneity.

【 授权许可】

Unknown