期刊论文详细信息
The Egyptian Journal of Bronchology
The impact of secondhand smoke exposure on the pregnancy outcome: a prospective cohort study among Egyptian community
Eman Sobh1  Zeinab Adawy1  Asmaa Mahmoud Mohammed2  Adel Hasheesh3  Aziza Hussein Nassef4 
[1] Chest Diseases Department, Faculty of Medicine for Girls, Al-Azhar University;Department of Environmental and Occupational Medicine, National Research Centre;Department of Research of Children with Special Needs, National Research Centre;Gynecology and Obstetrics Department, Faculty of Medicine for Girls, Al-Azhar University;
关键词: Cotinine;    Environmental tobacco smoke;    Low birth weight;    Pregnancy outcome;    Secondhand smoke exposure;   
DOI  :  10.1186/s43168-021-00097-4
来源: DOAJ
【 摘 要 】

Abstract Background Secondhand smoke (SHS) exposure gained lesser interest than active smoking. There is evidence from previous studies that SHS exposure had negative effects on fetal growth. This study aimed to examine the effect of smoke exposure on pregnancy outcome and to evaluate the level of nicotine urinary end-product cotinine in pregnant women in the late trimester. We included 36 women with a history of SHS exposure and 48 women without a history of exposure; all were in last trimester of pregnancy. We measured cotinine level in urine and followed the two groups until delivery and recorded fetal outcomes. Fetal biophysical parameters and blood flow waveforms were measured using B-mode and Doppler ultrasonography, respectively. Results The total range of the urinary cotinine creatinine ratio (CCR) concentration in the SHS exposed pregnant women was 0.01–0.2, IQR = 0.18 ng/mg.cr, versus 0.01–0.1, and IQR = 0.03 ng/mg.cr in the non-exposed group. The mean value as well as the mean rank of CCR was significantly higher (0.1 ± 0.08 ng/mg.cr., 40.3 respectively) in the exposed pregnant women as compared to the non-exposed pregnant women ((0.04 ± 0.02), 29.3 respectively, p value < 0.05). Newborn of the exposed women had significantly low birth weight which negatively correlated with cotinine level and had a dose-response relationship. Conclusions SHS exposure had negative effects on fetal outcomes. Efforts should be utilized to increase awareness of the consequences of secondhand smoke on the fetus and strict follow-up of exposed women for early detection.

【 授权许可】

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