Cognitive impairments in treatment-resistant depression: Results from the French cohort of outpatients (FACE-DR)

Journal of Affective Disorders Reports

Y Dansou¹  M Walter²  E Haffen³  E Vilà⁴  L Anguill⁵  Rey⁶  M Carminati⁶  D Bennabi⁷  M Leboyer⁸  G Vaiva⁸  M Horn⁸  E Allauze⁹  O Godin^1,10  R Richieri^1,11  JB Genty^1,11  W El-Hage^1,11  J Petrucci^1,11  J Holtzmann^1,11  B Etain^1,11  C Scotto d'Apollonia^1,11  AS Nguon^1,11  M Meyrel^1,11  B Fredembach^1,11  B Aouizerate^1,11  F Molière^1,11  B Péran^1,11  V Camus^1,11  P Courtet^1,11  A Yrondi^1,11  A Bouvard^1,11  JM Dorey^1,11  PM Llorca^1,11  G Fond^1,11  A Vancappel^1,11  F Stéphan^1,12 

[1] CHRU de Tours, Pôle de Psychiatrie-Addictologie, Centre Régional de Psychotraumatologie CVL, Clinique Psychiatrique Universitaire, Tours, France;Centre de référence régional des pathologies anxieuses et de la dépression, Pôle de Psychiatrie Générale et Universitaire, CH Charles Perrens, Bordeaux, France;Corresponding author at: CHRU de Tours, Pôle de Psychiatrie-Addictologie, Centre Régional de Psychotraumatologie CVL, Clinique Psychiatrique Universitaire, Tours, France;Faculté de Médecine - Secteur Timone, Marseille Univ, EA 3279,Service d’Épidémiologie et d’Économie de la Santé. Unité de Recherche Clinique. Direction de la Recherche en Santé, 27 Boulevard Jean Moulin, Marseille 13005, France;Laboratoire Nutrition et Neurobiologie intégrée, UMR INRAE 1286, Université de Bordeaux, France;Service Hospitalo-Universitaire de Psychiatrie Générale et de Réhabilitation Psycho Sociale, Brest, France;Service Hospitalo-Universitaire de Psychiatrie, CHU Grenoble Alpes, Univ. Grenoble Alpes, Grenoble, France;Service de Psychiatrie et de Psychologie Médicale de l'adulte, Centre Expert Dépression Résistante FondaMental, CHU de Toulouse, Hôpital Purpan, Toulouse, France;ToNIC Toulouse NeuroImaging Center, Université de Toulouse, INSERM, UPS, Toulouse, France;UMR 1253, iBrain, Université de Tours, Inserm, Tours, France;Fondation FondaMental, Créteil, France;INSERM U955, Équipe de Psychiatrie Translationnelle, Université Paris-Est Créteil, DHU Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil, France;

关键词: Treatment resistant depression;    Cognitive impairments;    Neuropsychology;    Memory;    Executive function;    Processing speed;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction: Previous studies set out cognitive impairments in major depression. However, only two studies were performed among patients suffering from treatment-resistant depression (TRD) and conducted on limited sample sizes. Here, we aimed to characterize cognitive impairments in TRD, and their association with the severity of depression and daily functioning. Method: We included 288 patients suffering from TRD (178 women, 52.5 ± 13.1 years old). They undertook sociodemographic, clinical, daily functioning and neuropsychological testing (TMT, Baddeley task, verbal fluencies, WAIS-4 subtests, D2 and RLRI-16). We compared our patients’ performances to theoretical performances of the general population. Results: TRD was associated with poorer neuropsychological performances, except for similarities task. We found an effect of depression severity on processing speed and memory, and an impact on daily functioning affecting memory, selective attention and executive function. Conclusion: Patients suffering from TRD have significant cognitive impairments. Therapeutic interventions should be developed to manage such impairments.

【 授权许可】

Unknown