iNOS Gene Ablation Prevents Liver Fibrosis in Leptin-Deficient ob/ob Mice

Genes

Victoria Catalán¹  Sara Becerril¹  Gema Frühbeck¹  Beatriz Ramírez¹  Xabier Unamuno¹  Javier Gómez-Ambrosi¹  Amaia Rodríguez¹ 

[1] Metabolic Research Laboratory, Clínica Universidad de Navarra, Pamplona, Spain;

关键词: Leptin, iNOS, Tenascin C, liver fibrosis, inflammation;   

DOI  :  10.3390/genes10030184

来源: DOAJ

【 摘 要 】

iNOS deficiency in ob/ob mice improved liver inflammation and ECM remodeling-related genes, decreasing fibrosis, and metabolic dysfunction. The activation of iNOS by leptin is necessary for the synthesis and secretion of TNC in hepatocytes, suggesting an important role of this alarmin in the development of NAFLD.

【 授权许可】

Unknown