Research Progress on Mono-ADP-Ribosyltransferases in Human Cell Biology

Frontiers in Cell and Developmental Biology

Huanhuan Sha¹  Yuan Zhang¹  Jianzhong Wu¹  Miao Xu²  Renrui Zou²  Yujie Gan²  Jifeng Feng² 

[1] Jiangsu Cancer Hospital, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China;Nanjing Medical University, Nanjing, China;

关键词: ADP-ribosylation;    PARP;    mono-ADP-ribosyltransferases;    NAD+;    MARylation;   

DOI  :  10.3389/fcell.2022.864101

来源: DOAJ

【 摘 要 】

ADP-ribosylation is a well-established post-translational modification that is inherently connected to diverse processes, including DNA repair, transcription, and cell signaling. The crucial roles of mono-ADP-ribosyltransferases (mono-ARTs) in biological processes have been identified in recent years by the comprehensive use of genetic engineering, chemical genetics, and proteomics. This review provides an update on current methodological advances in the study of these modifiers. Furthermore, the review provides details on the function of mono ADP-ribosylation. Several mono-ARTs have been implicated in the development of cancer, and this review discusses the role and therapeutic potential of some mono-ARTs in cancer.

【 授权许可】

Unknown