Disorders of Bone Mineral Density and Secondary Osteoporosis in Pathology of Hepatobiliary System and Gastrointestinal Tract: at the Crossing of Problems

Bolʹ, Sustavy, Pozvonočnik

I.Yu. Golovach¹ 

[1] Clinical Hospital Feofaniya of State Affairs Department, Kyiv;

关键词: osteoporosis, bone tissue;    bone mineral density;    chronic pancreatitis;    excretory failure;    cirrhosis;    chronic hepatitis;    inflammatory bowel diseases;    celiac disease;    cholelithiasis;   

DOI  :  10.22141/2224-1507.3.07.2012.82648

来源: DOAJ

【 摘 要 】

This review article covers the issues of development of osteoporosis and disorders of bone mineral density in patients with various gastroenterological and hepatobiliary diseases. The article emphasized that the osteoporosis may be associated with many somatic diseases, especially of the digestive tract. Such situation requires participation of therapeutists and gastroenterologists in rehabilitation health care programs. According to the practical guidelines of the World Organization of Gastroenterology (OMGE, 2004) list of chronic diseases of the digestive system triggering the dangerous development of osteoporosis includes short bowel syndrome, postgastrectomy syndrome, inflammatory bowel disease, celiac disease, cholestatic liver disease, as well as glucocorticoid-induced osteoporosis. The etiology and pathogenesis of lower bone mineral density in patients with chronic diseases of the digestive system include, besides population-based risk factors, processes associated with disorders of vitamin D conversion, which leads to reduction of the absorption of calcium, magnesium and phosphorus in the intestine and increase of their excretion by the kidneys. Hypocalcemia results in activation of the parathyroid glands and secondary hyperparathyroidism, and against the background of chronic inflammation increases the activity of cytokines, in particular tumor necrosis factor α and interleukins-1, -6, having bone resorptive action. The main risk factors for osteoporosis for various diseases associated with the peculiarities of the digestive tract’ disease were identified.

【 授权许可】

Unknown