Aptamer-Functionalized Nanoparticles in Targeted Delivery and Cancer Therapy

International Journal of Molecular Sciences

Jim Xiang¹  Zhaoying Fu² 

[1] Division of Oncology, University of Saskatchewan, Saskatoon, SK S7N 4H4, Canada;Institute of Molecular Biology and Immunology, College of Medicine, Yanan University, Yanan 716000, China;

关键词: aptamer;    nanoparticle;    delivery;    cancer;   

DOI  :  10.3390/ijms21239123

来源: DOAJ

【 摘 要 】

Using nanoparticles to carry and delivery anticancer drugs holds much promise in cancer therapy, but nanoparticles per se are lacking specificity. Active targeting, that is, using specific ligands to functionalize nanoparticles, is attracting much attention in recent years. Aptamers, with their several favorable features like high specificity and affinity, small size, very low immunogenicity, relatively low cost for production, and easiness to store, are one of the best candidates for the specific ligands of nanoparticle functionalization. This review discusses the benefits and challenges of using aptamers to functionalize nanoparticles for active targeting and especially presents nearly all of the published works that address the topic of using aptamers to functionalize nanoparticles for targeted drug delivery and cancer therapy.

【 授权许可】

Unknown