Vitamin K and Osteoporosis

Nutrients

Giovanni Tripepi¹  MariaLuisa Brandi²  Maurizio Gallieni³  Gaetano La Manna⁴  Giuseppe Cianciolo⁴  Lorenzo Gasperoni⁴  Sandro Giannini⁵  Andrea Aghi⁵  Stefania Sella⁵  ThomasL. Nickolas⁶  Serge Ferrari⁷  Angela M. Cheung⁸  Roberto Vettor⁹  Martina Zaninotto^1,10  Mario Plebani^1,10  Maria Fusaro^1,11  Giorgio Iervasi^1,11 

[1] CNR-IFC, Clinical Epidemiology of Renal Diseases and Hypertension, Ospedali Riuniti, 89124 Reggio Calabria, Italy;Department of Biomedical Experimental and Clinical Sciences “Mario Serio”, University of Florence, 50139 Florence, Italy;Department of Biomedical and Clinical Sciences ‘Luigi Sacco’, Università di Milano, 20157 Milano, Italy;Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, S. Orsola Hospital, University of Bologna, 40138 Bologna, Italy;Department of Medicine, Clinica Medica 1, University of Padua, 35128 Padua, Italy;Department of Medicine, Division of Nephrology, Columbia University, New York, NY 10032, USA;Department of Medicine, Service of Bone Diseases, Faculty of Medicine and Geneva University Hospital, 1205 Geneva, Switzerland;Department of Medicine, University Health Network, University of Toronto, 200 Elizabeth Street, Eaton North 7-221, Toronto, ON M5G 2C4, Canada;Department of Medicine, University of Padova, 35128 Padova, Italy;Laboratory Medicine Unit, Department of Medicine, University of Padua, 35128 Padua, Italy;National Research Council (CNR), Institute of Clinical Physiology (IFC), 56124 Pisa, Italy;

关键词: vitamin K;    vitamin K-dependent proteins;    Osteocalcin;    matrix Gla protein;    vitamin K levels;    vitamin K deficiency;   

DOI  :  10.3390/nu12123625

来源: DOAJ

【 摘 要 】

Vitamin K acts as a coenzyme of carboxylase, catalyzing the carboxylation of several vitamin K dependent proteins. Beyond its well-known effects on blood coagulation, it also exerts relevant effects on bone and the vascular system. In this review, we point out the relevance of an adequate vitamin K intake to obtain sufficient levels of carboxylated (active form) vitamin K dependent proteins (such as Osteocalcin and matrix Gla protein) to prevent bone health. Another bone-related action of Vitamin K is being a ligand of the nuclear steroid and xenobiotic receptor (SXR). We also discuss the recommended intake, deficiency, and assessment of vitamin K. Furthermore, we review the few available studies that have as pre-specified outcome bone fractures, indicating that we need more clinical studies to confirm that vitamin K is a potential therapeutic agent for bone fractures.

【 授权许可】

Unknown