The Role of Feedback Loops in Targeted Therapy for Pancreatic Cancer

Frontiers in Oncology

HongZhang Shen¹  Jianfeng Yang¹  Weigang Gu¹  Lu Xie¹  Xiaofeng Zhang² 

[1] Department of Gastroenterology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, China;Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou, China;

关键词: pancreatic cancer;    feedback loops;    targeted therapy;    negative regulation;    positive regulation;   

DOI  :  10.3389/fonc.2022.800140

来源: DOAJ

【 摘 要 】

Pancreatic cancer is the leading cause of cancer-related deaths worldwide, with limited treatment options and low long-term survival rates. The complex and variable signal regulation networks are one of the important reasons why it is difficult for pancreatic cancer to develop precise targeted therapy drugs. Numerous studies have associated feedback loop regulation with the development and therapeutic response of cancers including pancreatic cancer. Therefore, we review researches on the role of feedback loops in the progression of pancreatic cancer, and summarize the connection between feedback loops and several signaling pathways in pancreatic cancer, as well as recent advances in the intervention of feedback loops in pancreatic cancer treatment, highlighting the potential of capitalizing on feedback loops modulation in targeted therapy for pancreatic cancer.

【 授权许可】

Unknown