Efficient computation of the inverse of gametic relationship matrix for a marked QTL

Genetics Selection Evolution

关键词: BLUP;    indirect method;    inverse of gametic relationship matrix;    marked QTL;    tabular method;   

DOI  :  10.1186/1297-9686-38-3-253

来源: DOAJ

【 摘 要 】

Abstract

Best linear unbiased prediction of genetic merits for a marked quantitative trait locus (QTL) using mixed model methodology includes the inverse of conditional gametic relationship matrix (G^-1) for a marked QTL. When accounting for inbreeding, the conditional gametic relationships between two parents of individuals for a marked QTL are necessary to build G^-1 directly. Up to now, the tabular method and its adaptations have been used to compute these relationships. In the present paper, an indirect method was implemented at the gametic level to compute these few relationships. Simulation results showed that the indirect method can perform faster with significantly less storage requirements than adaptation of the tabular method. The efficiency of the indirect method was mainly due to the use of the sparseness of G^-1. The indirect method can also be applied to construct an approximate G^-1 for populations with incomplete marker data, providing approximate probabilities of descent for QTL alleles for individuals with incomplete marker data.

【 授权许可】

Unknown