Disposable Pencil Graphite Electrode for Diosmin Voltammetric Analysis

Micromachines

Alexandra-Gabriela Oancea¹  DanaElena Popa¹  IuliaGabriela David¹  Mihaela Buleandră¹  EmiliaElena Iorgulescu¹  AdelaMagdalena Ciobanu² 

[1] Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, Panduri Av. 90-92, District 5, 050663 Bucharest, Romania;Discipline of Psychiatry, Neurosciences Department, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Dionisie Lupu Street 37, 020021 Bucharest, Romania;

关键词: diosmin;    disposable working electrode;    pencil graphite electrode;    cyclic voltammetry;    differential pulse voltammetry;    adsorptive stripping voltammetry;   

DOI  :  10.3390/mi12040351

来源: DOAJ

【 摘 要 】

Diosmin (DIO) is a naturally occurring flavonoid with multiple beneficial effects on human health. The presence of different hydroxyl groups in diosmin structure enables its electrochemical investigation and quantification. This work presents, for the first time, diosmin voltammetric behavior and quantification on the cost-effective, disposable pencil graphite electrode (PGE). Diosmin oxidation on PGE involves two irreversible steps, generating products with reversible redox behaviors. All electrode processes are pH-dependent and predominantly adsorption-controlled. Differential pulse (DPV) and adsorptive stripping differential pulse (AdSDPV) voltammetric methods have been optimized for diosmin quantification o an H-type PGE, in 0.100 mol/L H₂SO₄. The linear ranges and limits of detection were for DPV 1.00 × 10⁻⁶–1.00 × 10⁻⁵ mol/L and 2.76 × 10⁻⁷ mol/L DIO for DPV and 1.00 × 10⁻⁷–2.50 × 10⁻⁶ mol/L and 7.42 × 10⁻⁸ mol/L DIO for AdSDPV, respectively. The DPV method was successfully applied for diosmin quantification in dietary supplement tablets. The percentage recovery was 99.87 ± 4.88%.

【 授权许可】

Unknown