Crosslinking of Chitosan with Dialdehyde Chitosan as a New Approach for Biomedical Applications

Materials

Dariusz T. Mlynarczyk¹  Tomasz Goslinski¹  Katarzyna Wegrzynowska-Drzymalska²  Dorota Chelminiak-Dudkiewicz²  Halina Kaczmarek²  Marta Ziegler-Borowska²  Patrycja Grebicka² 

[1] Chair and Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60780 Poznan, Poland;Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87100 Torun, Poland;

关键词: dialdehyde chitosan;    dialdehyde starch;    cross-linking;    chitosan;    Microtox® test;   

DOI  :  10.3390/ma13153413

来源: DOAJ

【 摘 要 】

Materials based on natural high molecular compounds are particularly interesting for biomedical applications. It is known that the cross-linking agent used for preparation of biomacromolecule-based materials is as important as used biopolymer. Therefore, natural cross-linkers containing reactive carbonyl groups are of great interest especially for modifying properties of natural polysaccharides. One of the most popular cross-linking agents is glutaraldehyde. Nevertheless, the unreacted particles can be released from the cross-linked material and cause cytotoxic effects. This can be eliminated when using a cross-linker based e.g., on polysaccharides. This article describes quick and efficient synthesis of dialdehyde chitosan (DACS) and its application for the preparation of chitosan films. Materials obtained with different amount of DACS were fully characterized in terms of structure and surface morphology. Thermal and mechanical properties as well as hydrophilic character were also examined. The results obtained were compared with the materials obtained by cross-linking chitosan with low molecular weight glutaraldehyde and high molecular weight cross-linking agent based on polysaccharide–dialdehyde starch. Toxicity of all obtained materials was tested using the Microtox® test. It has been shown that due to better mechanical, thermal and surface properties as well as lower toxicity, dialdehyde chitosan is a very promising crosslinking agent.

【 授权许可】

Unknown