An Outstanding Role of Adipose Tissue in Canine Stem Cell Therapy

Animals

Nina Krešić¹  Valentina Kunić¹  Dragan Brnić¹  Marina Prišlin¹  Ivana Lojkić¹  Nenad Turk²  Dunja Vlahović²  Petar Kostešić²  Tugomir Karadjole²  Ivana Ljolje³ 

[1] Croatian Veterinary Institute, Savska Cesta 143, 10000 Zagreb, Croatia;Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia;Veterinary Clinic for Small Animals Buba, Dore Pfanove 11, 10000 Zagreb, Croatia;

关键词: canine;    adipose-derived mesenchymal stem cells;    stem cell therapy;    regenerative veterinary medicine;    stromal vascular fraction;    adipose tissue;   

DOI  :  10.3390/ani12091088

来源: DOAJ

【 摘 要 】

Adipose tissue, previously known as connective tissue with a role in energy storage, is currently changing the course of treatments in veterinary medicine. Recent studies have revealed one particularly impressive function among all the newly discovered functions of adipose tissue. The interactive cells hosted by adipose tissue, the stromal vascular fraction (SVF), and their role in treating numerous diseases have provided a prospective course of research with positive outcomes in regenerative veterinary medicine (RVM). This review describes the main features of adipose tissue, emphasizing an eclectic combination of cells within the SVF and its thus far researched therapeutic possibilities in canine RVM. An afterwards focus is on a highly researched component of the SVF, adipose-derived mesenchymal stem cells (ASCs), which were shown to have an extraordinary impact relying on several proposed mechanisms of action on mitigating pathologies in canines. Furthermore, ASC therapy showed the most significant results in the orthopaedics field and in neurology, dermatology, ophthalmology, gastroenterology, and hepatology, which elevates the possibilities of ASC therapy to a whole new level. Therefore, this review article aims to raise awareness of the importance of research on cellular components, within abundant and easily accessible adipose tissue, in the direction of regenerative therapy in canines, considering the positive outcomes so far. Although the focus is on the positive aspects of cellular therapy in canines, the researchers should not forget the importance of identifying the potential negative aspects within published and upcoming research. Safe and standardized treatment represents a fundamental prerequisite for positively impacting the lives of canine patients.

【 授权许可】

Unknown