Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research

World Journal of Emergency Surgery

Annika Poppe¹  Karin Wodack¹  Constantin Trepte¹  Jakob R. Izbicki²  Kai Bachmann²  Katharina Grupp²  Johannes Erbes²  Oliver Mann²  Jan Havel²  Andreas Gocht³ 

[1] Centre of Anesthesiology and Intensive Care Medicine, University Medical Centre Hamburg-Eppendorf;Department of General, Visceral and Thoracic Surgery, University Medical Centre Hamburg-Eppendorf;Institute of Anatomy and Experimental Morphology, University Medical Center Hamburg-Eppendorf;

关键词: Acute pancreatitis;    Experimental model;    Melatonin;    Inflammation;    Edema;    Fitness score;   

DOI  :  10.1186/s13017-019-0237-2

来源: DOAJ

【 摘 要 】

Abstract Background Severe acute pancreatitis is associated with high morbidity and mortality. Melatonin is known as the activator of antioxidant enzymes. The main purpose of this study was to evaluate the clinical effect of melatonin treatment in a pig model with induced acute pancreatitis. Methods In this study, acute pancreatitis was induced in 38 German domestic pigs (German Hybrid). After induction of acute pancreatitis, 18 animals were treated with melatonin. Intraoperative clinical data, postoperative blood parameters, fitness, and Porcine Well-being (PWB) score, and post-mortal histopathological data were analyzed in both study groups. Results The matching procedure created two groups (melatonin group and control group) which were very similar. The fitness and PWB score were postoperative significantly enhanced in the melatonin group as compared to the control group (p = 0.005 and p = 0.003). Additionally, histological analysis revealed that acinar necrosis, fat tissue necrosis, and edema were significantly reduced in the melatonin group as compared to the non-melatonin group (p = 0.025, p = 0.003, and p = 0.028). Conclusions Pigs, which were treated with melatonin, were characterized by higher fitness and PWB scores than those of the control group. Moreover, melatonin treatment reduces the acinar necrosis, fat tissue necrosis, and edema of pancreatic tissue. Thus, melatonin might be a useful therapeutic option in severe acute pancreatitis.

【 授权许可】

Unknown